Hyaluronan: its nature, distribution, functions and turnover
نویسندگان
چکیده
منابع مشابه
Hyaluronan: its nature, distribution, functions and turnover.
Hyaluronan is a polysaccharide found in all tissues and body fluids of vertebrates as well as in some bacteria. It is a linear polymer of exceptional molecular weight, especially abundant in loose connective tissue. Hyaluronan is synthesized in the cellular plasma membrane. It exists as a pool associated with the cell surface, another bound to other matrix components, and a largely mobile pool....
متن کاملDistribution of hyaluronan in the epiphysial growth plate: turnover by CD44-expressing osteoprogenitor cells.
In the present study, we have examined the distribution of both hyaluronan and its receptor, CD44, during the process of endochondral ossification in the mouse tibia. Histochemical staining revealed that a large amount of hyaluronan was present in the lacunae located in the zone of hypertrophy, but it was greatly reduced or absent from the zone of erosion. In addition, hyaluronan was present in...
متن کاملHyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity
The molecular mechanisms whereby hyaluronan (HA) stimulates cell motility was investigated in a C-H-ras transformed 10T 1/2 fibroblast cell line (C3). A significant (p < 0.001) stimulation of C3 cell motility with HA (10 ng/ml) was accompanied by an increase in protein tyrosine phosphorylation as detected by anti-phosphotyrosine antibodies using immunoblot analysis and immunofluorescence staini...
متن کاملDistribution and Turnover
Received for publication 27 August 1968 and in revised form 14 February 1969. between 32 and 53 g. For each kilogram of excess weight the expected increments were 0.0220 g/day and 0.90 g, respectively. The plasma cholesterol concentration was not related to the production rate or to the amount of cholesterol in the two pools. It was, however, inversely related to the fractional rate of removal ...
متن کاملOral administration of hyaluronan reduces bone turnover in ovariectomized rats.
The effect of oral hyaluronan (HA) on bone loss in ovariectomized (OVX) 3-month-old rats was measured using serum markers of bone turnover and bone mineral density. OVX rats were administered 1 mg/kg HA (OVX + HA) or phosphate-buffered saline (PBS) (OVX + PBS) by oral gavage (5 days/week for 54 days). Additional controls included sham ovariectomy with PBS gavage (Sham + PBS) and no treatment. O...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 1997
ISSN: 0954-6820
DOI: 10.1046/j.1365-2796.1997.00170.x